mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3281-2. doi: 10.1073/pnas.1000323107. Epub 2010 Feb 18.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Gluconeogenesis / genetics*
  • Insulin / metabolism
  • Insulin / pharmacology
  • Insulin Resistance*
  • Lipogenesis / genetics*
  • Liver / metabolism
  • Mechanistic Target of Rapamycin Complex 1
  • Mice
  • Models, Animal
  • Multiprotein Complexes
  • Proteins
  • Sterol Regulatory Element Binding Protein 1 / genetics*
  • TOR Serine-Threonine Kinases
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Insulin
  • Multiprotein Complexes
  • Proteins
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases