Abstract
This article reviews the medicinal implications of 5-HT(4)R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT(4)R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.
MeSH terms
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Humans
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Ligands
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Receptors, Serotonin, 5-HT4 / metabolism
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Serotonin 5-HT4 Receptor Agonists*
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Serotonin 5-HT4 Receptor Antagonists*
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Serotonin Antagonists / chemistry
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Serotonin Antagonists / pharmacology*
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Serotonin Antagonists / therapeutic use*
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Serotonin Receptor Agonists / chemistry
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Serotonin Receptor Agonists / pharmacology*
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Serotonin Receptor Agonists / therapeutic use*
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Structure-Activity Relationship
Substances
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Ligands
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Serotonin 5-HT4 Receptor Agonists
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Serotonin 5-HT4 Receptor Antagonists
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Serotonin Antagonists
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Serotonin Receptor Agonists
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Receptors, Serotonin, 5-HT4