Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target

MeSH terms

• Binding Sites
• Carrier Proteins / antagonists & inhibitors*
• Carrier Proteins / metabolism
• Crystallography, X-Ray
• Drug Design
• Heterocyclic Compounds, 3-Ring / chemistry*
• Heterocyclic Compounds, 3-Ring / pharmacology
• Humans
• Intracellular Signaling Peptides and Proteins
• Macrocyclic Compounds / chemistry*
• Protease Inhibitors / chemistry*
• Protease Inhibitors / pharmacology
• Protein Binding
• Simeprevir
• Sulfonamides / chemistry*
• Sulfonamides / pharmacology
• Viral Nonstructural Proteins / antagonists & inhibitors*
• Viral Nonstructural Proteins / metabolism
• Viral Proteins / antagonists & inhibitors*
• Viral Proteins / metabolism