Multicomponent asymmetric reactions mediated by proline lithium salt

Org Biomol Chem. 2010 Mar 7;8(5):980-3. doi: 10.1039/b924158b. Epub 2010 Jan 13.

Abstract

The multicomponent reaction between proline lithium salt, 2-cyclohexen-1-one and aliphatic aldehydes affords the 4-alkylidene-2-cyclohexen-1-ones, which are interesting fragrances, and bicyclic amino acids that bear four additional stereocenters, obtained as single stereoisomer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Amino Acids / chemistry
  • Bridged Bicyclo Compounds / chemistry*
  • Catalysis
  • Cyclohexanones / chemistry
  • Lithium Compounds / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Proline / chemistry*
  • Salts / chemistry*

Substances

  • Aldehydes
  • Amino Acids
  • Bridged Bicyclo Compounds
  • Cyclohexanones
  • Lithium Compounds
  • Salts
  • 2-cyclohexen-1-one
  • Proline