Abstract
The multicomponent reaction between proline lithium salt, 2-cyclohexen-1-one and aliphatic aldehydes affords the 4-alkylidene-2-cyclohexen-1-ones, which are interesting fragrances, and bicyclic amino acids that bear four additional stereocenters, obtained as single stereoisomer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Amino Acids / chemistry
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Bridged Bicyclo Compounds / chemistry*
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Catalysis
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Cyclohexanones / chemistry
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Lithium Compounds / chemistry*
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Models, Molecular
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Molecular Structure
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Proline / chemistry*
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Salts / chemistry*
Substances
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Aldehydes
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Amino Acids
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Bridged Bicyclo Compounds
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Cyclohexanones
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Lithium Compounds
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Salts
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2-cyclohexen-1-one
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Proline