Abstract
Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / toxicity
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Azo Compounds / chemistry
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Cell Line, Tumor
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Cross-Linking Reagents / chemistry*
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Humans
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Methotrexate / chemistry*
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Methotrexate / toxicity
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Nanotubes, Carbon / chemistry*
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Nanotubes, Carbon / ultrastructure
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Thiosemicarbazones / chemistry
Substances
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Antineoplastic Agents
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Azo Compounds
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Cross-Linking Reagents
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Nanotubes, Carbon
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Thiosemicarbazones
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azomethine
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Methotrexate