Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases

BMC Genomics. 2010 Feb 10;11 Suppl 1(Suppl 1):S14. doi: 10.1186/1471-2164-11-S1-S14.

Abstract

A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Biocatalysis
  • Cell Cycle*
  • Computational Biology
  • Conserved Sequence
  • Humans
  • Microtubules / enzymology*
  • Models, Molecular
  • Molecular Sequence Data
  • Phosphorylation
  • Phylogeny
  • Plants / enzymology*
  • Plants / genetics
  • Protein Serine-Threonine Kinases / chemistry*
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism
  • Protein Structure, Tertiary
  • Sequence Alignment
  • Structural Homology, Protein

Substances

  • Protein Serine-Threonine Kinases