Polybioside, a neuroactive compound from the venom of the social wasp Polybia paulista

Daniel M Saidemberg; Luiz C da Silva-Filho; Lilian M M Cesar Tognoli; Claudio F Tormena; Mario S Palma

doi:10.1021/np900424t

Polybioside, a neuroactive compound from the venom of the social wasp Polybia paulista

J Nat Prod. 2010 Apr 23;73(4):527-31. doi: 10.1021/np900424t.

Authors

Daniel M Saidemberg¹, Luiz C da Silva-Filho, Lilian M M Cesar Tognoli, Claudio F Tormena, Mario S Palma

Affiliation

¹ Laboratory of Structural Biology and Zoochemistry, Department of Biology/CEIS, Institute of Biosciences, São Paulo State University (UNESP), 13506-900, Rio Claro, SP, Brazil.

PMID: 20158240
DOI: 10.1021/np900424t

Abstract

Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / cytology
Brain / drug effects
Brazil
Central Nervous System Agents / chemistry
Central Nervous System Agents / isolation & purification*
Central Nervous System Agents / pharmacology*
Glucosides / chemistry
Glucosides / isolation & purification*
Glucosides / pharmacology*
Imidazoles / chemistry
Imidazoles / isolation & purification*
Imidazoles / pharmacology*
Male
Molecular Structure
Neurons / drug effects
Nuclear Magnetic Resonance, Biomolecular
Proto-Oncogene Proteins c-fos / drug effects
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Wistar
Seizures / chemically induced
Wasp Venoms / chemistry*
Wasps / chemistry*

Substances

Central Nervous System Agents
Glucosides
Imidazoles
Proto-Oncogene Proteins c-fos
Wasp Venoms
polybioside