A new optical label-free biosensing platform based on a metal-insulator-metal structure

Langmuir. 2010 Apr 20;26(8):6053-7. doi: 10.1021/la903794b.

Abstract

A new label-free biosensing platform is proposed based on a metal-insulator-metal (MIM) structure. This platform allows us to perform biosensing by a simple reflectivity measurement at normal incidence illumination without using any bulky optical setup. Theoretical calculation was made to find optimized MIM structural parameters, and experimental results on the label-free biosensing using the MIM platform are presented. This platform has greater sensitivity and mass resolution with respect to the anomalous reflection method, which is a label-free biosensing platform previously proposed by us. Hence, it is suitable for high throughput analysis of biomolecular detection in a microarray format.

MeSH terms

  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • Gold / chemistry
  • Membranes, Artificial
  • Metals

Substances

  • Membranes, Artificial
  • Metals
  • Gold