Abstract
Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.
Keywords:
Aging; Life span; degenerative disease; oxidative stress.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Aging / genetics
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Aging / metabolism*
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Animals
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Gene Expression Regulation / physiology*
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Humans
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Longevity / genetics*
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Longevity / physiology
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Mutation
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Oxygen / metabolism
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Protein Isoforms
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Shc Signaling Adaptor Proteins / metabolism*
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Src Homology 2 Domain-Containing, Transforming Protein 1
Substances
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Protein Isoforms
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SHC1 protein, human
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Shc Signaling Adaptor Proteins
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Oxygen