Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog

J Am Chem Soc. 2010 Mar 10;132(9):3224-8. doi: 10.1021/ja9101503.

Abstract

A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Biological Products / chemistry*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology
  • Cell Movement / drug effects*
  • Drug Screening Assays, Antitumor
  • Ethers / chemical synthesis
  • Ethers / chemistry
  • Ethers / pharmacology*
  • Ethers / therapeutic use
  • Female
  • Humans
  • Macrolides / chemistry
  • Macrolides / pharmacology*
  • Macrolides / therapeutic use
  • Mice
  • Molecular Conformation
  • Neoplasm Metastasis / drug therapy*
  • Neoplasm Metastasis / pathology
  • Piperidones / chemistry
  • Piperidones / pharmacology*
  • Piperidones / therapeutic use
  • Stereoisomerism

Substances

  • Antineoplastic Agents
  • Biological Products
  • Ethers
  • Macrolides
  • Piperidones
  • migrastatin