Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii

Yusuke Hirasawa; Tomokazu Shoji; Takashi Arai; Alfarius E Nugroho; Jun Deguchi; Takahiro Hosoya; Nahoko Uchiyama; Yukihiro Goda; Khalijah Awang; A Hamid A Hadi; Motoo Shiro; Hiroshi Morita

doi:10.1016/j.bmcl.2010.01.051

Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii

Bioorg Med Chem Lett. 2010 Mar 15;20(6):2021-4. doi: 10.1016/j.bmcl.2010.01.051. Epub 2010 Jan 20.

Authors

Yusuke Hirasawa¹, Tomokazu Shoji, Takashi Arai, Alfarius E Nugroho, Jun Deguchi, Takahiro Hosoya, Nahoko Uchiyama, Yukihiro Goda, Khalijah Awang, A Hamid A Hadi, Motoo Shiro, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

PMID: 20153644
DOI: 10.1016/j.bmcl.2010.01.051

Abstract

A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apocynaceae / chemistry*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology
Magnetic Resonance Spectroscopy
Models, Molecular

Substances

Indole Alkaloids
bisleuconothine A