Dcr1 tracked down

Dev Cell. 2010 Jan 19;18(1):6-7. doi: 10.1016/j.devcel.2010.01.001.

Abstract

RNAi is essential for pericentromeric heterochromatic formation in S. pombe, and although Dcr1, the initiator protein of this process, has been biochemically well described, its subcellular localization has remained elusive. In this issue of Developmental Cell, Emmerth et al. now show that Dcr1 is dynamically shuttling between nucleus and cytoplasm, adding new insight into the subcellular mechanics of RNAi.

Publication types

  • Comment

MeSH terms

  • Active Transport, Cell Nucleus / genetics
  • Animals
  • Cell Nucleus / genetics*
  • Cell Nucleus / metabolism
  • Cytoplasm / genetics
  • Cytoplasm / metabolism
  • Heterochromatin / genetics
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Nuclear Pore / genetics
  • Nuclear Pore / metabolism
  • Protein Transport
  • RNA Interference / physiology*
  • Ribonuclease III / genetics*
  • Ribonuclease III / metabolism
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces / metabolism

Substances

  • Gid8 protein, S cerevisiae
  • Heterochromatin
  • Intracellular Signaling Peptides and Proteins
  • Ribonuclease III