Targeting the checkpoint kinase WEE1: selective sensitization of cancer cells to DNA-damaging drugs

Cancer Biol Ther. 2010 Apr 1;9(7):523-5. doi: 10.4161/cbt.9.7.11276. Epub 2010 Apr 1.
No abstract available

Publication types

  • Comment

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cell Cycle Proteins / antagonists & inhibitors*
  • Cell Cycle Proteins / metabolism
  • Colonic Neoplasms / drug therapy*
  • Colonic Neoplasms / pathology*
  • DNA Damage / drug effects*
  • Humans
  • Nuclear Proteins / antagonists & inhibitors*
  • Nuclear Proteins / metabolism
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / metabolism
  • Pyrazoles / pharmacology*
  • Pyrimidines / pharmacology*
  • Pyrimidinones

Substances

  • Antineoplastic Agents
  • Cell Cycle Proteins
  • Nuclear Proteins
  • Pyrazoles
  • Pyrimidines
  • Pyrimidinones
  • Protein-Tyrosine Kinases
  • WEE1 protein, human
  • adavosertib