Stem cell therapies for ocular surface disease

Drug Discov Today. 2010 Apr;15(7-8):306-13. doi: 10.1016/j.drudis.2010.02.001. Epub 2010 Feb 10.

Abstract

Transparency of the cornea on the front surface of the eye is essential for vision. A variety of blinding ocular surface diseases involve the cornea. This review focusses on vision loss caused by disruption of the integrity and function of the outermost corneal layer (the epithelium) and the stem-cell-based therapeutic strategies in use and under development to restore sight in affected patients.

Publication types

  • Review

MeSH terms

  • Animals
  • Cells, Cultured
  • Cornea / pathology
  • Corneal Diseases / pathology
  • Corneal Diseases / therapy*
  • Embryonic Stem Cells
  • Epithelial Cells / transplantation
  • Epithelium, Corneal / pathology
  • Humans
  • Pluripotent Stem Cells
  • Stem Cell Transplantation*
  • Treatment Outcome