Isolated symptomatic cutaneous disease in hypereosinophilic syndrome

Australas J Dermatol. 2010 Feb;51(1):60-5. doi: 10.1111/j.1440-0960.2009.00610.x.

Abstract

A 41-year-old Phillipino man presented with a 3-year history of a relapsing and remitting generalized chronic pruritic erythematous papular and plaque-like eruption. Investigations showed a persistently elevated eosinophil count. His disease was limited to cutaneous involvement with an absence of demonstrable internal organ involvement, despite extensive investigations and multidisciplinary review. Other causes of eosinophilia were excluded. A diagnosis of idiopathic hypereosinophilic syndrome was made. Our patient's presentation raises a number of issues related to hypereosinophilic syndrome. In particular, relating to managing hypereosinophilic syndrome and the challenge of minimizing therapy side-effects. Our case highlights the considerable morbidity of untreated isolated cutaneous disease, for which he was hospitalized with suicidal ideations. In a minority of reports, skin involvement is the only manifestation of hypereosinophilic syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Humans
  • Hypereosinophilic Syndrome / complications
  • Hypereosinophilic Syndrome / diagnosis*
  • Hypereosinophilic Syndrome / pathology
  • Male
  • Pruritus / diagnosis*
  • Pruritus / etiology
  • Pruritus / pathology
  • Suicide / psychology