The efficacy of an enterosorbent based on low-esterified pectin, activated charcoal, and polyphepan was evaluated in rats with experimental renal failure. Pectin was shown to be most effective. Its use causes increased daily diuresis and lower blood urine and creatinine levels in experimental animals. The findings have led to the conclusion that low-esterified pectin may be used to design drugs for the complex treatment in patients with chronic renal failure.