Translational research, which can be explained as the principle of combining advances in both basic research and clinical understanding in a bedside-to-bench-to-bedside approach, has become one of the central themes of present-day medical research. One orthopedic problem that has strongly benefited from such an approach is tissue-engineering-enhanced primary repair of the anterior cruciate ligament. Recent years have shown a clearer definition of the clinical problem and established an underlying mechanistic cause of the incapacity of the anterior cruciate ligament to heal-the premature loss of provisional scaffold in the wound site. These clinical findings were then translated into a research objective, namely, to replace the missing scaffold with a biomaterial with appropriate structural and bio-stimulatory characteristics. Subsequently, a tissue-engineering-based treatment using a collagen-platelet composite was developed and tested in vitro. After proofing the efficacy of this new treatment in the laboratory, it was translated into a potential clinical application, which showed highly successful results in structural integrity and biomechanical capacity in large animal testing. This approach of defining the scientific mechanism underlying a clinical observation and then using that information to design new therapies is but one example of how translational research in tissue engineering can help define and develop new treatments for challenging problems faced by patients.