Blocking the deadly effects of the NMDA receptor in stroke

Cell. 2010 Jan 22;140(2):174-6. doi: 10.1016/j.cell.2010.01.014.

Abstract

Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-associated protein kinase 1 with the NMDA receptor, thereby potentiating its activity, and show that disrupting this association reduces damage to the brain.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / antagonists & inhibitors
  • Apoptosis Regulatory Proteins / metabolism*
  • Brain / metabolism
  • Brain / pathology
  • Brain Ischemia / metabolism
  • Brain Ischemia / pathology
  • Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Death-Associated Protein Kinases
  • Peptides / metabolism
  • Receptors, N-Methyl-D-Aspartate / metabolism*
  • Stroke / drug therapy
  • Stroke / metabolism*
  • Stroke / pathology

Substances

  • Apoptosis Regulatory Proteins
  • NR2B NMDA receptor
  • Peptides
  • Receptors, N-Methyl-D-Aspartate
  • Death-Associated Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases