Abstract
Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-associated protein kinase 1 with the NMDA receptor, thereby potentiating its activity, and show that disrupting this association reduces damage to the brain.
Copyright 2010 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Apoptosis Regulatory Proteins / antagonists & inhibitors
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Apoptosis Regulatory Proteins / metabolism*
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Brain / metabolism
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Brain / pathology
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Brain Ischemia / metabolism
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Brain Ischemia / pathology
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Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors
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Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
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Death-Associated Protein Kinases
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Peptides / metabolism
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Receptors, N-Methyl-D-Aspartate / metabolism*
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Stroke / drug therapy
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Stroke / metabolism*
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Stroke / pathology
Substances
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Apoptosis Regulatory Proteins
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NR2B NMDA receptor
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Peptides
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Receptors, N-Methyl-D-Aspartate
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Death-Associated Protein Kinases
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Calcium-Calmodulin-Dependent Protein Kinases