[Identification of a new human leukocyte antigen A allele, HLA-A*3020]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Feb;27(1):96-9. doi: 10.3760/cma.j.issn.1003-9406.2010.01.021.
[Article in Chinese]

Abstract

Objective: To identify a novel human leukocyte antigen (HLA) A allele.

Methods: A new HLA-A allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).

Results: The novel HLA-A*30 allele was identical to A*300101 except that a nucleotide C at position 294 of exon 2 is substituted by A, resulting in codon 98 changed from GAC (D) to GAA (E).

Conclusion: A new HLA allele, HLA-A*3020, was identified, and was named officially by the WHO Nomenclature Committee.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Base Sequence
  • HLA-A Antigens / chemistry
  • HLA-A Antigens / genetics*
  • Humans
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Analysis, DNA

Substances

  • HLA-A Antigens