Stimulation of protective and cross-protective immunity against influenza B virus after adjuvant mucosal immunization of mice

Folia Microbiol (Praha). 2009 Nov;54(6):549-52. doi: 10.1007/s12223-009-0080-z. Epub 2010 Feb 7.

Abstract

Intratracheal immunization of mice with inactivated influenza B virus and delipidated Bacillus firmus as adjuvant increases protection of mice against infection with the homologous virus strain and induces cross-protection: mice immunized by influenza virus B/Yamanashi 166/98 were protected even against phylogenetically distant virus drift variant B/Lee/40 lethal for mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Administration, Inhalation
  • Animals
  • Bacillus / immunology
  • Cross Protection
  • Female
  • Immunization / methods*
  • Influenza B virus / immunology*
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Orthomyxoviridae Infections / immunology
  • Orthomyxoviridae Infections / prevention & control
  • Survival Analysis
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / immunology

Substances

  • Adjuvants, Immunologic
  • Influenza Vaccines
  • Vaccines, Inactivated