Although intussusception is the main cause of intestinal obstruction in the pediatric population, it is a rare condition in adults, and when it happens, the clinical characteristics differ a lot from the pediatric group. The purpose of this article is to report a case of a 16 years-old male that was seen at the Emergency Room of the University Hospital of São Paulo with an intestinal intussusception as the first clinical presentation of a Burkitt lymphoma. A literature review was carried out and relevant aspects of the case are discussed.