Abstract
Four compounds were isolated from the broth culture of Volvariella bombycina and they were identified as ergosta-4,6,8(14),22-tetraene-3-one (1), ergosterol peroxide (2), indole-3-carboxaldehyde (3) and indazole (4) by interpretation of spectroscopic data. Among them, compound 2 exhibited melanogenesis inhibitory effect in cultured B16 mouse melanoma cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Factors / metabolism*
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Biological Factors / pharmacology*
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Cell Survival / drug effects
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Ergosterol / analogs & derivatives
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Ergosterol / metabolism
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Ergosterol / pharmacology
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Indazoles / metabolism
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Indazoles / pharmacology*
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Melanins / biosynthesis
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Melanoma, Experimental / metabolism*
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Metabolism / drug effects*
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Mice
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Volvariella / chemistry
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Volvariella / metabolism*
Substances
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Biological Factors
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Indazoles
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Melanins
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ergosterol-5,8-peroxide
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Ergosterol