Secondary metabolites of Volvariella bombycina and their inhibitory effects on melanogenesis

J Microbiol Biotechnol. 2010 Jan;20(1):78-81.

Abstract

Four compounds were isolated from the broth culture of Volvariella bombycina and they were identified as ergosta-4,6,8(14),22-tetraene-3-one (1), ergosterol peroxide (2), indole-3-carboxaldehyde (3) and indazole (4) by interpretation of spectroscopic data. Among them, compound 2 exhibited melanogenesis inhibitory effect in cultured B16 mouse melanoma cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Factors / metabolism*
  • Biological Factors / pharmacology*
  • Cell Survival / drug effects
  • Ergosterol / analogs & derivatives
  • Ergosterol / metabolism
  • Ergosterol / pharmacology
  • Indazoles / metabolism
  • Indazoles / pharmacology*
  • Melanins / biosynthesis
  • Melanoma, Experimental / metabolism*
  • Metabolism / drug effects*
  • Mice
  • Volvariella / chemistry
  • Volvariella / metabolism*

Substances

  • Biological Factors
  • Indazoles
  • Melanins
  • ergosterol-5,8-peroxide
  • Ergosterol