IDH1 gene mutations: a new paradigm in glioma prognosis and therapy?

Oncologist. 2010;15(2):196-9. doi: 10.1634/theoncologist.2009-0218. Epub 2010 Feb 4.

Abstract

The manuscript examines the role of isocitrate dehydrogenase 1 and the IDH1 gene in the prognosis and therapy of glial tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Neoplasms / enzymology
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / therapy*
  • Glioblastoma / enzymology
  • Glioblastoma / genetics
  • Glioblastoma / therapy
  • Glioma / enzymology
  • Glioma / genetics*
  • Glioma / therapy*
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Point Mutation*
  • Prognosis

Substances

  • Isocitrate Dehydrogenase
  • IDH1 protein, human