Acid and base degraded products of ketorolac

J Pharm Biomed Anal. 2010 Jun 5;52(2):320-2. doi: 10.1016/j.jpba.2010.01.031. Epub 2010 Jan 21.

Abstract

The stability of ketorolac tromethamine was investigated in acid (0.5M HCl) and alkaline conditions (0.5M NaOH), using the same procedure reported by Devarajan et al. [2]. The acid and base degradation products were identified by liquid chromatography-mass spectrometry (LC-MS).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / analysis
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Chromatography, Liquid / methods
  • Drug Stability
  • Hot Temperature
  • Hydrochloric Acid / chemistry
  • Hydrolysis
  • Ketorolac / analysis
  • Ketorolac / chemistry*
  • Mass Spectrometry / methods
  • Methanol / chemistry
  • Molecular Structure
  • Molecular Weight
  • Reference Standards
  • Sodium Hydroxide / chemistry*
  • Solvents / chemistry
  • Time Factors

Substances

  • Acids
  • Anti-Inflammatory Agents, Non-Steroidal
  • Solvents
  • Sodium Hydroxide
  • Hydrochloric Acid
  • Methanol
  • Ketorolac