Evidence for neuronal expression of functional Fc (epsilon and gamma) receptors

J Allergy Clin Immunol. 2010 Mar;125(3):757-60. doi: 10.1016/j.jaci.2009.10.054. Epub 2010 Feb 4.

Abstract

We report that neurons express functional Fc receptors (including FcεR1), that can be activated by antigen, transmit signals along nerve fibers in vitro and in vivo. These results open new avenues of investigation in neurogenic inflammation and allergic diseases.

Publication types

  • Letter
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Communication / physiology*
  • Mice
  • Neurons / metabolism*
  • RNA, Messenger / analysis
  • Receptors, IgE / biosynthesis*
  • Receptors, IgG / biosynthesis*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction / physiology*

Substances

  • RNA, Messenger
  • Receptors, IgE
  • Receptors, IgG