C(3)-symmetric chiral trisimidazoline: design and application to organocatalyst

Org Lett. 2010 Mar 5;12(5):964-6. doi: 10.1021/ol902958m.

Abstract

C(3)-symmetric chiral trisimidazoline was designed and synthesized as a new entry of organocatalyst with the concept of constructing C(3)-symmetric molecules with three C(2)-symmetric chiral components, and the application of this novel catalyst to asymmetric conjugate addition of beta-ketoesters to nitroolefins was described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry
  • Catalysis
  • Drug Design*
  • Esters / chemistry
  • Imidazolines / chemistry*
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Alkenes
  • Esters
  • Imidazolines