To develop a practical clinical decision support system (CDSS) for acu-moxibustion therapy is of highly realistic significance in assisting acupuncturists with their decision-making tasks. In the present paper, the authors review the general state of studies on CDSS and analyze the extant problems and those needing to be tackled urgently in acu-moxibustion clinic. Secondly, the authors put forward some thoughts on developing CDSS for acu-moxibustion and analyze its practicability. In conclusion, the authors think that by making full use of modern methodology of evidence-based medicine and utilizing the abundant available information of current databases and data mining techniques, to develop a practical CDSS for acu-moxibustion is necessary.