Synthesis and characterization of a redox- and light-sensitive MRI contrast agent

Chuqiao Tu; Elizabeth A Osborne; Angelique Y Louie

doi:10.1016/j.tet.2008.12.020

Synthesis and characterization of a redox- and light-sensitive MRI contrast agent

Tetrahedron. 2009 Feb;65(7):1241. doi: 10.1016/j.tet.2008.12.020.

Authors

Chuqiao Tu¹, Elizabeth A Osborne, Angelique Y Louie

Affiliation

¹ Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.

Abstract

A redox- and light-sensitive, T(1)-weighted magnetic resonance imaging (MRI) contrast agent which tethers a spiropyran(SP)/merocyanine(MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form which has an r(1) relaxivity of 2.51 mM(-1)s(-1) (60MHz, 37°C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r(1) relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.

Abstract

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