The active search for occupational neoplasms has been implemented only in Italy. This search can be carried out with two modalities: the in-hospital face-to-face interview of selected cancer cases, and the linkage of available information (OCCAM). Both were supported by a special project on occupational carcinogenesis of the Lombardy Region. The active search for occupational neoplasms is a moderate-cost activity and is important for the safeguard of the workforce and of the population as a whole.