Myopericytoma is a rare mesenchymal neoplasm with perivascular myoid differentiation. Myopericytoma arises most commonly in middle adulthood. The lesion generally involves the distal extremities; however, tumors can also arise at other sites, including the proximal extremities and head and neck. In this case report, a 43-year-old Chinese woman presented with a painless slowly growing nodule in her right cheek. Biopsy revealed a periluminal proliferation of monomorphic oval to spindle-shaped myoid-appearing cells. Immunohistochemistry showed a positive staining for smooth muscle actin. The clinical, pathologic, and immunohistochemical features are discussed. To our knowledge, this is the first case report in the medical literature of multifocal myopericytoma in the maxillofacial region.
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