WT1 the oncogene: a tale of death and HtrA

Mol Cell. 2010 Jan 29;37(2):153-5. doi: 10.1016/j.molcel.2010.01.010.

Abstract

Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

Publication types

  • Comment

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Apoptosis* / drug effects
  • Genes, Wilms Tumor / physiology*
  • High-Temperature Requirement A Serine Peptidase 2
  • Humans
  • Mitochondrial Proteins / metabolism
  • Mitochondrial Proteins / physiology*
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Serine Endopeptidases / metabolism
  • Serine Endopeptidases / physiology*
  • Stress, Physiological
  • WT1 Proteins / chemistry
  • WT1 Proteins / genetics
  • WT1 Proteins / physiology

Substances

  • Antineoplastic Agents
  • Mitochondrial Proteins
  • WT1 Proteins
  • Serine Endopeptidases
  • HTRA2 protein, human
  • High-Temperature Requirement A Serine Peptidase 2