Abstract
Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apiaceae / chemistry*
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Cell Line, Tumor
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Cell Survival / drug effects
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Coumarins / chemistry
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Coumarins / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Plant Roots / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Coumarins
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aegelinol