Phytotoxic activity of Salvia x jamensis

Nat Prod Commun. 2009 Dec;4(12):1621-30.

Abstract

A study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant phytotoxic activity against Papaver rhoeas L. and Avena sativa L.. Bioguided separation of the exudate yielded active fractions from which 3 beta-hydroxy-isopimaric acid (1), hautriwaic acid (2), betulinic acid (3), 7,8 beta-dihydrosalviacoccin (4), isopimaric acid (5), 14 alpha-hydroxy-isopimaric acid (7), 15,16-epoxy-7 alpha, 10 beta-dihydroxy-clerod-3,13(16),14-trien-17,12;18,19-diolide (8), cirsiliol (5,3',4'-trihydroxy-6,7-dimethoxyflavone, 9) and two new neoclerodane diterpenes (6 and 10) were isolated. The structures of 6 and 10 were identified as 15,16-epoxy-10 beta-hydroxy-clerod-3,13(16),14-trien-17,12;18,19-diolide and 15,16-epoxy-7 alpha,10-dihydroxy-clerod-2,13(16),14-trien-17,12;18,19-diolide respectively on the basis of spectroscopic data analysis. All compounds, but 7, 8 and 10, were active in inhibiting the germination of the tested species.

MeSH terms

  • Avena / drug effects
  • Avena / growth & development
  • Avena / metabolism
  • Chlorophyll / metabolism
  • Dose-Response Relationship, Drug
  • Germination / drug effects
  • Herbicides / chemistry*
  • Herbicides / toxicity
  • Magnetic Resonance Spectroscopy
  • Papaver / drug effects
  • Papaver / growth & development
  • Papaver / metabolism
  • Salvia / toxicity*
  • Seeds / drug effects
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Herbicides
  • Chlorophyll