Abstract
Four novel octanorcucurbitane triterpenes, octanorcucurbitacins A-D (1-4), together with one known octanorcucurbitane triterpene, kuguacin M (5), were isolated from the methyl alcohol extract of the stems of Momordica charantia. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 3 inhibited tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity against HepG2 cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Survival / drug effects
-
Cytoprotection*
-
Glycosides / analysis*
-
Glycosides / isolation & purification
-
Glycosides / pharmacology*
-
Hep G2 Cells
-
Hepatocytes / cytology
-
Hepatocytes / drug effects*
-
Humans
-
Molecular Structure
-
Momordica charantia / chemistry*
-
Triterpenes / analysis*
-
Triterpenes / isolation & purification
-
Triterpenes / pharmacology*
-
tert-Butylhydroperoxide / adverse effects*
Substances
-
Glycosides
-
Triterpenes
-
cucurbitane
-
tert-Butylhydroperoxide