Abstract
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Administration, Oral
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Animals
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry*
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Antiviral Agents / therapeutic use
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Cell Line
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Female
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Hepatitis B / drug therapy*
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Hepatitis B virus / genetics*
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Humans
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Male
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Mice
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Mice, Transgenic
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Mutation
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Nucleotides / chemical synthesis
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Nucleotides / chemistry*
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Nucleotides / therapeutic use
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Prodrugs / chemical synthesis
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Prodrugs / chemistry*
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Prodrugs / therapeutic use
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Rats
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Rats, Sprague-Dawley
Substances
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Antiviral Agents
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Nucleotides
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Prodrugs