Retention of Naproxen enantiomers on the chiral stationary phase Whelk-O1 under reversed-phase conditions. A reconsideration of the adsorption mechanism in the light of new experimental data

Leonid D Asnin; Georges Guiochon

doi:10.1016/j.chroma.2010.01.017

Retention of Naproxen enantiomers on the chiral stationary phase Whelk-O1 under reversed-phase conditions. A reconsideration of the adsorption mechanism in the light of new experimental data

J Chromatogr A. 2010 Mar 5;1217(10):1709-11. doi: 10.1016/j.chroma.2010.01.017. Epub 2010 Jan 18.

Authors

Leonid D Asnin¹, Georges Guiochon

Affiliation

¹ Institute of Technical Chemistry, The Ural Branch of the Russian Academy of Sciences, Perm 614990, Russia.

PMID: 20116794
DOI: 10.1016/j.chroma.2010.01.017

Abstract

A model of adsorption of the Naproxen enantiomers on the (S,S)-Whelk-O1 chiral stationary phase that we recently proposed was found to be inconsistent with new experimental data. A new model taking into account the variation of the dissociation coefficient of the analyte during elution of the band is discussed.

MeSH terms

Adsorption
Chromatography, Reverse-Phase / instrumentation*
Chromatography, Reverse-Phase / methods
Naproxen / chemistry*
Resins, Synthetic / chemistry
Stereoisomerism

Substances

Resins, Synthetic
Naproxen