Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1)

Food Chem Toxicol. 2010 Jan:48 Suppl 1:S34-41. doi: 10.1016/j.fct.2009.10.037.

Abstract

Aflatoxin B1 (AFB1) has been consistently shown to be a potent mutagen and is a liver carcinogen in humans and a wide range of animal species. The Fisher rat appears to be the most sensitive animal model. Dose-response modelling results in a BMDL(10) of 250 ng/kg-bw/d. Estimates of mean dietary exposure estimates were 0.4 ng/kg-bw/d and 2.6 ng/kg-bw/d, representing regions with low and high exposure, respectively. The MOEs for mean exposure therefore range from 100 to 600.

Publication types

  • Review

MeSH terms

  • Aflatoxin B1 / toxicity*
  • Animals
  • Carcinogens / toxicity*
  • Data Interpretation, Statistical
  • Diet
  • Dose-Response Relationship, Drug
  • Female
  • Food Contamination / analysis*
  • Humans
  • Male
  • Models, Statistical
  • Mutagens / toxicity*
  • Neoplasms / chemically induced
  • Neoplasms / epidemiology
  • Rats

Substances

  • Carcinogens
  • Mutagens
  • Aflatoxin B1