Bipolar electrosurgical approach represents an increasingly acknowledged technology in the treatment of benign prostatic hyperplasia (BPH), and a promising alternative to standard transurethral resection of the prostate (TURP). In this study, we aimed to evaluate a new method, transurethral resection in saline - plasma vaporization of the prostate (TURIS-PVP), by determining its efficiency, safety and short-term postoperative results. In May 2009, TURIS-PVP was performed in 25 cases of BPH. The investigative protocol included digital rectal examination (DRE), prostatic specific antigen (PSA), International Prostate Symptom Score (IPSS), quality of life (QoL) score, maximum flow rate (Qmax) and abdominal ultrasonography assessing prostate volume and post-voiding residual urinary volume (RV). All patients were investigated 1 month after surgery using IPSS, QoL, Qmax and RV. TURIS-PVP was successfully performed in all cases. The average BPH size was 53 ml, the mean operating time was 28 minutes, the median catheterization time was 24 hours and the mean hospital stay was 48 hours. No patient required blood transfusions or re-catheterization, and there were no significant intra- or postoperative complications. Preoperatively, the mean value of IPSS was 21.4, the mean QoL score was 4, the mean RV was 72 ml and the mean Qmax was 9.7 ml/s. The 1 month follow-up emphasized a mean IPSS of 4, a mean QoL score of 1.4, a mean RV of 14 ml and a mean Qmax of 21.5 ml/s. TURIS-PVP represents a valuable endoscopic treatment alternative for patients with BPH, with good efficacy, reduced morbidity, satisfactory follow-up parameters and fast postoperative recovery. IPSS, QoL, Qmax and RV measurements showed significant improvements at the 1 month follow-up.