Synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential

Gisell Apicela Soares; Renata Barbosa de Oliveira; Saulo Fernandes de Andrade; Ricardo José Alves; Carlos Leomar Zani; Elaine Maria de Souza-Fagundes

doi:10.3390/molecules15010012

Synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential

Molecules. 2009 Dec 24;15(1):12-26. doi: 10.3390/molecules15010012.

Authors

Gisell Apicela Soares¹, Renata Barbosa de Oliveira, Saulo Fernandes de Andrade, Ricardo José Alves, Carlos Leomar Zani, Elaine Maria de Souza-Fagundes

Affiliation

¹ Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Av. Augusto de Lima 1715, Belo Horizonte, MG 30190-002, Brazil.

Abstract

In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Caspase 3 / metabolism
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
DNA Fragmentation / drug effects
DNA, Neoplasm / analysis
Drug Screening Assays, Antitumor
Enzyme Activation / drug effects
Flow Cytometry
Humans

Substances

Antineoplastic Agents
DNA, Neoplasm
Caspase 3