Enantioselective synthesis of planar-chiral phosphaferrocenes by molybdenum-catalyzed asymmetric interannular ring-closing metathesis

Masamichi Ogasawara; Susumu Watanabe; Kiyohiko Nakajima; Tamotsu Takahashi

doi:10.1021/ja910348z

Enantioselective synthesis of planar-chiral phosphaferrocenes by molybdenum-catalyzed asymmetric interannular ring-closing metathesis

J Am Chem Soc. 2010 Feb 24;132(7):2136-7. doi: 10.1021/ja910348z.

Authors

Masamichi Ogasawara¹, Susumu Watanabe, Kiyohiko Nakajima, Tamotsu Takahashi

Affiliation

¹ Catalysis Research Center and Graduate School of Life Science, Hokkaido University, Kita-ku, Sapporo 001-0021, Japan. ogasawar@cat.hokudai.ac.jp

PMID: 20108921
DOI: 10.1021/ja910348z

Abstract

Enantioselective synthesis of planar-chiral phosphaferrocenes was realized for the first time by molybdenum-catalyzed asymmetric ring-closing metathesis (ARCM) in up to 99% ee, which is the first application of ARCM to induction of chirality in molecules devoid of stereogenic centers.