[Analysis of a severe septic transfusion reaction with standard platelet concentrate]

R Courbil; J-P Romaszko; H Odent-Malaure; P Fabrigli; P Chavarin; O Tournilhac; J-O Bay; P Fressy; A Ergani; A Bouvet; R Bonnet; O Garraud

doi:10.1016/j.tracli.2009.12.002

[Analysis of a severe septic transfusion reaction with standard platelet concentrate]

Transfus Clin Biol. 2010 Feb;17(1):9-13. doi: 10.1016/j.tracli.2009.12.002. Epub 2010 Jan 27.

[Article in French]

Authors

R Courbil¹, J-P Romaszko, H Odent-Malaure, P Fabrigli, P Chavarin, O Tournilhac, J-O Bay, P Fressy, A Ergani, A Bouvet, R Bonnet, O Garraud

Affiliation

¹ EFS Auvergne-Loire, boulevard Pasteur, Saint-Etienne, France. remi.courbil@efs.sante.fr

PMID: 20106699
DOI: 10.1016/j.tracli.2009.12.002

Abstract

We recently observed a near fatal case of transfusion-transmitted infection with standard platelet concentrate. Streptococcus dysgalactiae subspecies equisimilis was isolated both from donor, residual component container and cultures of the patient's blood. This should question the usefulness of systematic bacterial detection in platelet concentrates, however a lethal accident has occurred recently which escaped bacterial detection. This observation calls for implementation of pathogen inactivation procedures for platelets concentrates.

Publication types

Case Reports
English Abstract

MeSH terms

Bacteremia / diagnosis
Bacteremia / microbiology
Bacteremia / transmission*
Bacterial Typing Techniques
Blood Donors
Equipment Contamination
Female
Humans
Leukemia, Myeloid, Acute / complications
Mass Screening
Middle Aged
Pharynx / microbiology
Platelet Transfusion / adverse effects*
Platelet Transfusion / instrumentation
Shock, Septic / etiology*
Shock, Septic / microbiology
Species Specificity
Streptococcal Infections / diagnosis
Streptococcal Infections / transmission*
Streptococcus / isolation & purification*
Thrombocytopenia / etiology
Thrombocytopenia / therapy