Markedly different cytotoxicity of the two enantiomers of C(2)-symmetrical Ti(IV) phenolato complexes; mechanistic implications

Cesar M Manna; Edit Y Tshuva

doi:10.1039/b920786b

Markedly different cytotoxicity of the two enantiomers of C(2)-symmetrical Ti(IV) phenolato complexes; mechanistic implications

Dalton Trans. 2010 Feb 7;39(5):1182-4. doi: 10.1039/b920786b. Epub 2009 Nov 2.

Authors

Cesar M Manna¹, Edit Y Tshuva

Affiliation

¹ Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

PMID: 20104339
DOI: 10.1039/b920786b

Abstract

The two enantiomers of a member of the highly active C(2)-symmetrical bis(isopropoxo) Ti(iv) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / toxicity
Cell Line, Tumor
Coordination Complexes / chemical synthesis
Coordination Complexes / chemistry*
Coordination Complexes / toxicity
Crystallography, X-Ray
Diamines / chemistry
HT29 Cells
Humans
Molecular Conformation
Stereoisomerism
Titanium / chemistry*

Substances

Antineoplastic Agents
Coordination Complexes
Diamines
Titanium