With the advancement of laparoscopic equipment and growing operational experience, the number of case reports or descriptions of series of nephrectomies performed in patients with the preoperative diagnosis of venous system involvement has become more frequent in the medical literature. In this article, we present the case of a laparoscopic nephrectomy performed with retroperitoneoscopic access for preoperatively diagnosed renal vein and vena cava thrombus. Operation time was 130 minutes and blood loss was 50 mL. The weight of the specimen was 460 g. The postoperative course was uncomplicated. The pathology report revealed pT3b clear cell cancer (Fuhrman grade 2) with negative margins on the venous cutting line.