A case of chikungunya fever imported from India to Japan, follow-up of specific IgM and IgG antibodies over a 6-month period

Jpn J Infect Dis. 2010 Jan;63(1):65-6.

Abstract

Chikungunya fever is an arboviral disease caused by chikungunya virus. A 37-year-old Japanese male visited India and developed fever, myalgia, rash, and persisting systemic arthralgia, the latter of which persisted for more than 2 months. The patient was diagnosed with chikungunya fever by virological and serological examinations. In the present study, we followed specific antibody responses over a 6-month period after the onset of the disease. IgM antibody was detected on days 58 and 108, but not on day 137, by enzyme-linked immunosorbent assay. Specific IgG and neutralizing antibodies were detected as late as day 192. The results indicate that specific IgM lasts for 3 to 4 months from the onset of the disease, and that IgG lasts more than 6 months.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alphavirus Infections / diagnosis*
  • Alphavirus Infections / pathology
  • Alphavirus Infections / virology
  • Antibodies, Viral / blood
  • Chikungunya virus / isolation & purification*
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • India
  • Japan
  • Male
  • Travel

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M