Catalytic asymmetric total synthesis of tangutorine

Org Lett. 2010 Feb 19;12(4):872-5. doi: 10.1021/ol902929a.

Abstract

The first enantioselective total synthesis of tangutorine has been achieved, wherein a Pd-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand was the key step.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allyl Compounds / chemistry
  • Amination
  • Carbolines / chemical synthesis*
  • Carbolines / chemistry
  • Catalysis
  • Drugs, Chinese Herbal / chemical synthesis*
  • Drugs, Chinese Herbal / chemistry
  • Molecular Structure
  • Palladium / chemistry
  • Quinolizines / chemical synthesis*
  • Quinolizines / chemistry
  • Stereoisomerism

Substances

  • Allyl Compounds
  • Carbolines
  • Drugs, Chinese Herbal
  • Quinolizines
  • tangutorine
  • Palladium