Abstract
The first enantioselective total synthesis of tangutorine has been achieved, wherein a Pd-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand was the key step.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allyl Compounds / chemistry
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Amination
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Carbolines / chemical synthesis*
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Carbolines / chemistry
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Catalysis
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Drugs, Chinese Herbal / chemical synthesis*
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Drugs, Chinese Herbal / chemistry
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Molecular Structure
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Palladium / chemistry
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Quinolizines / chemical synthesis*
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Quinolizines / chemistry
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Stereoisomerism
Substances
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Allyl Compounds
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Carbolines
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Drugs, Chinese Herbal
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Quinolizines
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tangutorine
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Palladium