Fossils as candidate material for orthopedic applications

J Biomater Appl. 2011 Jan;25(5):445-67. doi: 10.1177/0885328209358630. Epub 2010 Jan 20.

Abstract

Ceramic powders from fossil deposits were thoroughly characterized from the material point of view and sintered to produce massive components. The raw material, a mixture of apatite minerals, feldspars, and quartz, seems ideally suitable to obtain a biologically compatible glass ceramic. Preliminary in vitro tests of proliferation and adhesion of MG63 human osteoblast-like cell line on a selected sample are encouraging. Results are correlated with sintering conditions and phase composition: the fossil can be sintered to almost full density at temperatures as low as 900 °C and seems to quickly promote cell activation with respect to hydroxylapatite.

MeSH terms

  • Aluminum Silicates / chemistry
  • Aluminum Silicates / isolation & purification
  • Animals
  • Apatites / chemistry
  • Apatites / isolation & purification
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / isolation & purification
  • Bone Substitutes / chemistry
  • Bone Substitutes / isolation & purification
  • Cell Adhesion
  • Cell Line
  • Cell Proliferation
  • Cell Survival
  • Ceramics / chemistry
  • Ceramics / isolation & purification
  • Fossils*
  • Hot Temperature
  • Humans
  • In Vitro Techniques
  • Materials Testing
  • Microscopy, Confocal
  • Microscopy, Electron, Scanning
  • Orthopedic Procedures
  • Osteoblasts / cytology
  • Potassium Compounds / chemistry
  • Potassium Compounds / isolation & purification
  • Powder Diffraction
  • Powders
  • Quartz / chemistry
  • Quartz / isolation & purification
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Aluminum Silicates
  • Apatites
  • Biocompatible Materials
  • Bone Substitutes
  • Potassium Compounds
  • Powders
  • feldspar
  • Quartz