Relationship of gastric cancer with the presence of IL-10-592 polymorphism was reported with inconsistent results. The objective of this study was to quantitatively evaluate the association between IL-10-592 allele polymorphism and gastric cancer susceptibility. We performed an extensive search of relevant studies and made a meta-analysis, including 12 studies with 2,285 gastric cancer cases and 4,236 controls. The combined results based on all studies showed that there were no significant differences in genotype distribution between gastric cancer cases and controls, CC versus CA/AA (OR = 1.05, 95% CI: 0.92-1.18), CC/CA versus AA (OR = 1.16, 95% CI: 0.92-1.46), CC versus CA (OR = 1.03, 95% CI: 0.90-1.17), CC versus AA (OR = 1.10, 95% CI: 0.90-1.34), and CA versus AA (OR = 1.16, 95% CI: 0.92-1.45). When stratifying for the race, it was found that gastric cancer cases had a significantly higher frequency of CC/CA versus AA (OR = 1.31, 95% CI: (1.08-1.59) and a significantly upper frequency of CA versus AA (OR = 1.33, 95% CI: 1.09-1.63) than control in Asians. When stratifying for the location and the Lauren's classification of gastric cancer, there were no statistically significant differences in genotype distribution between gastric cancer cases and controls. This meta-analysis suggested that IL-10-592 allele polymorphism might be a risk factor for gastric cancer among Asians.