Final report on the safety assessment of amino nitrophenols as used in hair dyes

Int J Toxicol. 2009 Nov-Dec;28(6 Suppl 2):217S-51S. doi: 10.1177/1091581809354651.

Abstract

2-Amino-3-nitrophenol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 4-amino-2-nitrophenol, 2-amino-4-nitrophenol sulfate, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are substituted aromatic compounds used as semipermanent (nonoxidative) hair colorants and as toners in permanent (oxidative) hair dye products. All ingredients in this group except 2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, and 4-amino-2-nitrophenol have reported uses in cosmetics at use concentrations from 2% to 9%. The available toxicity studies for these amino nitrophenol hair dyes did not suggest safety concerns except for the potential carcinogenicity and mutagenicity of 4-amino-2-nitrophenol. 2-Amino-3-nitrophenol, 2-amino-4-nitrophenol, 2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are safe as hair dye ingredients in the practices of use and concentration as described in this safety assessment, but the data are insufficient to make a safety determination for 4-amino-2-nitrophenol.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / drug effects
  • Bacteria / genetics
  • Carcinogenicity Tests
  • Carcinogens / toxicity
  • Cosmetics
  • Drug Contamination
  • Eye Diseases / chemically induced
  • Eye Diseases / pathology
  • Female
  • Hair Dyes / analysis
  • Hair Dyes / chemistry
  • Hair Dyes / pharmacokinetics
  • Hair Dyes / toxicity*
  • Humans
  • Irritants / toxicity
  • Mutagenicity Tests
  • Mutagens / toxicity
  • Neoplasms / chemically induced
  • Neoplasms / epidemiology
  • Nitrophenols / analysis
  • Nitrophenols / chemistry
  • Nitrophenols / pharmacokinetics
  • Nitrophenols / toxicity*
  • Pregnancy
  • Rabbits
  • Reproduction / drug effects
  • Safety
  • Skin Diseases / chemically induced
  • Skin Diseases / pathology
  • Tissue Distribution

Substances

  • Carcinogens
  • Cosmetics
  • Hair Dyes
  • Irritants
  • Mutagens
  • Nitrophenols