An important goal in the preparation of highly active supported metal particles is the enhancement of the metal support interaction, providing a more stable catalyst, especially for liquid phase reactions as the leaching and reconstruction of the active phase causes deactivation. In this work, a covalent triazine framework (CTF) as support for Pd nanoparticles is compared to activated carbon (AC), the typical support used in liquid phase reactions. The results indicate that the presence of the N-heterocyclic moieties on the surface of the frameworks is beneficial for improving the stability of Pd nanoparticles during the liquid phase glycerol oxidation. Pd/CTF showed better activity and in particular better stability when compared to Pd supported on activated carbon (AC).