The right team at the right time to go for a home run: tyrosine kinase activation by the TCR

Nat Immunol. 2010 Feb;11(2):101-4. doi: 10.1038/ni0210-101.

Abstract

The TCR signals via cytoplasmic tyrosine kinases. Art Weiss recounts discoveries that led to early understanding of these events.

Publication types

  • Historical Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allergy and Immunology / history*
  • Enzyme Activation / physiology*
  • Female
  • History, 20th Century
  • Humans
  • Protein-Tyrosine Kinases / immunology
  • Protein-Tyrosine Kinases / metabolism*
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism*
  • Signal Transduction / immunology*

Substances

  • Receptors, Antigen, T-Cell
  • Protein-Tyrosine Kinases